hsp-16.2 Heat shock protein hsp-16.2;SHSP domain-containing protein [Caenorhabditis elegans]

Gene ID: 178659, updated on 23-May-2024

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Summary

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Gene symbol: hsp-16.2
Gene description: Heat shock protein hsp-16.2;SHSP domain-containing protein
Primary source: WormBase:WBGene00002016
Locus tag: CELE_Y46H3A.3
See related: AllianceGenome:WB:WBGene00002016
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Involved in response to heat. Located in cytoplasm. Is expressed in several structures, including enteric muscle; gonad; somatic nervous system; sperm; and spermatid. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to several human genes including CRYAB (crystallin alpha B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See hsp-16.2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 2

Sequence:: Chromosome: V; NC_003283.11 (1804334..1804957, complement)

Chromosome V - NC_003283.11

Genomic regions, transcripts, and products

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Show that the bidirectional hsp-16.2/41 promoter interacts with the nuclear pore complex upon activation by heat shock in the nematode Caenorhabditis elegans in an RNAse polymerase II dependent manner.
Title: Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y46H3A.d (e-PCR)
- UniSTS:322905

Y46H3A.e (e-PCR)
- UniSTS:322906

hom*ology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Heat shock protein hsp-16.2;SHSP domain-containing protein

NP_001294665.1

Confirmed by transcript evidence

NP_001379929.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11Reference assembly

Range

1804334..1804957 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392482.1 → NP_001379929.1 Heat shock protein hsp-16.2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P06582

UniProtKB/TrEMBL

Q21062

Conserved Domains (1) summary

cd06526
Location:42 → 123

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_001307736.3 → NP_001294665.1 SHSP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294665.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21062, V6CLQ2

Conserved Domains (1) summary

cd06526
Location:24 → 105

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...